Two sample MR report
LAP3_Monocyte (Mono) against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | -0.0566244 | 0.6019254 | 0.9271128 |
| Weighted median | 11 | 0.1098545 | 0.0332351 | 0.0009485 |
| Inverse variance weighted | 11 | 0.1100710 | 0.0251996 | 0.0000125 |
| Simple mode | 11 | 0.1213664 | 0.0459258 | 0.0246213 |
| Weighted mode | 11 | 0.1046892 | 0.0449148 | 0.0419903 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.5751788 | 9 | 0.9999446 |
| Inverse variance weighted | 0.6520075 | 10 | 0.9999766 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0674368 | 0.243296 | 0.7879031 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001747 | 0 | TRUE | 0.2113637 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
